Observational studyAmerican journal of hypertension2026
Whole-body and intracellular arginine metabolism in hypertension: role of disease severity and sex.
Observational study in American journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 21 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in Chronic Obstructive Pulmonary Disease (COPD): Aim 2
Metabolic and Functional Changes in Relation to Nutritional Status in Chronic Heart Failure and Chronic Obstructive Pulmonary Disorder
Effects of Chemotherapy and Nutritional Intervention on Gut Function and Metabolism in Cancer
The Effect of Chemotherapy on Fat Metabolism and Digestion and Function in Breast Cancer Patients.
Validation Of A New Method To Simultaneously Measure Protein Digestion And Absorption
Effects of Alpha-lactalbumin on Metabolic and Cognitive Functions in Healthy Older Adults
Fat Metabolism and Digestion in Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease
Anabolic Responsiveness to Protein Intake in Chronic Heart Failure and Chronic Obstructive Pulmonary Disorder
Omics Profiling of the Response to Food and Variability of Weight Loss in Medically Supervised Very Low Calorie Diet
The Effects of Acute Resistance Exercise on Protein and Amino Acid Metabolism in Chronic Obstructive Pulmonary Disease
Human Metabolism of HMB
Human Metabolism of Ornithine Phenylacetate: A Study in Healthy Volunteers
Short-chain Fatty Acid Metabolism in Chronic Obstructive Pulmonary Disease
Effects of Low Dose of Fish Oil (EPA+DHA) vs. Combined EPA+DHA and HMB Supplementation on Protein Metabolism, Muscle Mass and Functional Capacity in Moderate to Severe COPD
Isoleucine Intake and Intermediary Metabolism in Type 2 Diabetes
The Relation Between the Meal Macronutrient Distribution and Plasma Metabolites to Model the Composition of Meals of Patients With Diabetes II and Cardiovascular Disease.
Metabolic and Functional Consequences of Aging in Health and Disease
Circuit-Exercise Training on Subjects With and Without Chronic Respiratory Disease
Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein
Effects of Oral Nutritional Supplement and Acute Resistance Exercise in Chronic Obstructive Pulmonary Disease
Nutritional Supplementation in Patient With Stable COPD and in Those Recovering From an Acute Exacerbation of COPD: the Effects on Metabolism and Clinical Status
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
backgroundArginine, as precursor of the antihypertensive metabolite nitric oxide, may influence blood pressure (BP) regulation and is therefore linked to hypertension, a serious global health issue. Thus, we investigated whether hypertension relates to alterations in arginine metabolism and examined the role of biological sex and body composition.
methodsWe stratified 762 older adults (50-95 years old) participating in the MEDIT-trial into 4 BP groups (normal, elevated, stage 1 and 2 hypertension) per 2025 ACC/AHA guidelines. Body composition was assessed by dual-energy X-ray absorptiometry. After administering stable tracers of arginine, citrulline, and ornithine, blood samples were taken to measure postabsorptive plasma amino acid concentrations and tracer enrichments by LC-MS/MS. Compartmental modeling was applied to determine amino acid kinetics.
resultsAge and glucose, hs-CRP, and arginine levels were comparable across groups. Older adults with stage 1 and stage 2 hypertension had higher BMIs than those with normal BP (29.7 kg/m2 and 31.0 kg/m2 vs. 27.8 kg/m2). Whole-body and intracellular arginine production in stage 2 hypertension were increased by 10.4% and 10.7% compared to those with normotension (all: P < .05), particularly in females (whole-body: +13.7%; intracellular: +18.3%; all: P < .02). While females showed progressive increases in body composition parameters along BP groups, males displayed relatively stable values.
conclusionsArginine metabolism in older adults is influenced by hypertension severity, with sex-specific differences in metabolic adaptation. Further research is warranted determining whether hypertension treatment for older adults should be individualized to disease severity, accounting for the upregulated arginine metabolism and sex-specific differences, which may lead to improved outcomes. CLINICAL
trial registrationwww.clinicalTrials.gov, Trial Numbers: NCT01787682, NCT01871350, NCT01624792, NCT01890824, NCT02082418, NCT02157844, NCT06801964, NCT02065141, NCT03159390, NCT02770092, NCT02908425, NCT02780219, NCT02780206, NCT03327181, NCT06801951, NCT03796455, NCT04928872, NCT04461236, NCT05395390, NCT05240885, NCT06628349.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.