Evidence map›Paper›PMID 42149728›Full record

ArticleThe Journal of general virology2026

Strain-specific pathogenicity and antibody-dependent enhancement of dengue virus infection in

Takayuki Hishiki, Milagros Virhuez-Mendoza, Yusuke Sakai, Akihiko Uda, Seiya Ozono, Yuko Sato, Sorane Machiya, Kotomi Sato, Yuta Utsui, Shigeru Tajima and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Takayuki HishikiDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Milagros Virhuez-MendozaDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Yusuke SakaiDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Akihiko UdaDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Seiya OzonoDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Yuko SatoDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Sorane MachiyaDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Kotomi SatoDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Yuta UtsuiDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Shigeru TajimaDepartment of Virology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Chang-Kweng LimDepartment of Virology I, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Akitoyo HottaDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Yudai KurodaDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Tsukasa YamamotoDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Yoshimasa TakahashiResearch Center for Vaccine Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Tadaki SuzukiDepartment of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Koichi WatashiDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.
Ken MaedaDepartment of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the pathogenicity of various dengue virus (DENV) strains using a newly established double-knockout (DKO) mouse model lacking both type I and type II IFN receptors (

Indexed as

Antibody-Dependent EnhancementDengueDengue VirusReceptor, Interferon alpha-betaReceptors, InterferonAnimalsAntibodies, ViralBrainDisease Models, AnimalInterferon gamma ReceptorMiceMice, Inbred C57BLMice, KnockoutSpinal CordSurvival AnalysisVirulenceAntibodies, ViralIfnar1 protein, mouseInterferon gamma ReceptorReceptor, Interferon alpha-betaReceptors, Interferonantibody-dependent enhancement (ADE)dengue virus (DENV)Ifnar1–Ifngr1 double-knockout (DKO) micemouse model

Identifiers

PMID42149728
PMCPMC13192526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.