Evidence map›Paper›PMID 42149720›Full record

ArticleFEBS open bio2026

The C-terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice.

Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai and 10 more

Abstract read
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In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuta YamamuraDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.ORCID https://orcid.org/0000-0003-3713-0733
Kengo FuruichiDepartment of Nephrology, Kanazawa Medical University, Uchinada, Japan.
Hiromitsu AkamatsuDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Naoki YamamotoDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Sako KeisukeDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Akihiko KoshinoDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Taichiro MinamiDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Megumi OshimaDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Akinori HaraDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Norihiko SakaiDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Miho ShimizuDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Kenta TakahashiDepartment of Human Pathology, Kanazawa University, Japan.
Minako YamamuraDepartment of Human Pathology, Kanazawa University, Japan.
Shin-Ichi HorikeDivision of Integrated Omics Research, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Japan.ORCID https://orcid.org/0000-0002-4256-9129
Takiko DaikokuDivision of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Japan.
Kenichi HaradaDepartment of Human Pathology, Kanazawa University, Japan.
Yohei ShinmyoDepartment of Neurophysiology, Hamamatsu University School of Medicine, Japan.
Hiroshi KawasakiDepartment of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Japan.
Takashi WadaDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.
Yasunori IwataDepartment of Nephrology and Rheumatology, Kanazawa University, Japan.

Funding

Japan Agency for Medical Research and Development JP256f0137001Japan Society for the Promotion of Science JP22K16236
6 · The paper itself

Abstract

Loss of Kif26b function causes renal agenesis or hypoplasia in mice, and a KIF26B mutation resulting in deletion of the C-terminal region has been identified in a human patient with a congenital kidney disorder. However, the role of this region during kidney development is unclear; thus, to investigate this, we generated mice lacking the C-terminal region of KIF26B (Kif26b-C) using CRISPR/Cas9. Homozygous Kif26b-C mice showed bilateral renal agenesis, resembling Kif26b knockout mice. Histological analysis revealed loss of the nephrogenic zone and impaired nephron progenitor condensation at embryonic day 18.5. In situ hybridization showed reduced Gdnf in the metanephric mesenchyme and reduced Wnt11 in ureteric buds, indicating disruption of the Gdnf-Wnt11 signaling loop. These findings suggest a key role for the KIF26B C-terminal region in kidney morphogenesis.

Indexed as

KidneyKinesinsNephronsAnimalsCongenital AbnormalitiesKidney DiseasesMiceMice, KnockoutKinesinsCAKUTkidney developmentKif26bPAX2renal coloboma syndrome

Identifiers

PMID42149720
PMCPMC13398707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.