Evidence map›Paper›PMID 42149693›Full record

ArticleFunction (Oxford, England)2026

Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

Xin C Davis, Colin S McCoin, Sebastian F Salathe, Edziu Franczak, Julie A Allen, Eric D Queathem, Kyle L Fulghum, Patrycja Puchalska, Peter A Crawford, John P Thyfault and 1 more

Abstract read
In one paragraph

Article in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Xin C DavisDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Colin S McCoinDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Sebastian F SalatheDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Edziu FranczakDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Julie A AllenDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Eric D QueathemDepartment of Internal Medicine, Division of Molecular Metabolism, University of Minnesota, Minneapolis, Minnesota, United States.
Kyle L FulghumDepartment of Internal Medicine, Division of Molecular Metabolism, University of Minnesota, Minneapolis, Minnesota, United States.
Patrycja PuchalskaDepartment of Internal Medicine, Division of Molecular Metabolism, University of Minnesota, Minneapolis, Minnesota, United States.
Peter A CrawfordDepartment of Internal Medicine, Division of Molecular Metabolism, University of Minnesota, Minneapolis, Minnesota, United States.
John P ThyfaultDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.
E Matthew MorrisDepartment of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0001-7046-3623

Funding

longitudinal assessment of stress and stress-related concepts across a behavioral weight loss interventionP20GM144269 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Paige C Geiger · 2022 to 2026
$14.9M
Ketogenic Oscillations and Neurometabolic HealthspanR01AG069781 · NIA · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, THYFAULT, JOHN P · 2020 to 2024
$2.3M
Hepatic mitochondrial function control of high-fat diet-induced weight gainK01DK112967 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MORRIS, E MATTHEW · 2017 to 2021
$872k
Translating Obesity, Metabolic Dysfunction and Comorbid Disease StatesT32DK128770 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John P Thyfault, Douglas E Wright · 2022 to 2026
$806k
Metabolic Phenotyping ClusterS10OD028598 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2020 to 2020
$602k
NIA NIH HHS R01 AG069781NIDDK NIH HHS K01 DK112967NIDDK NIH HHS T32 DK128770NIGMS NIH HHS P20 GM144269NIH HHS S10 OD028598
6 · The paper itself

Abstract

Ketone body (KB) utilization increases during fasting and exercise due to enhanced hepatic fatty acid oxidation and KB production via the rate-limiting mitochondrial enzyme hydroxymethylglutaryl-CoA synthase (HMGCS2). Since KB metabolism intersects with multiple metabolic pathways and skeletal muscle KB catabolism rises during exercise, we tested the hypothesis that liver-specific HMGCS2 knockouts (KO) would have reduced energy expenditure (EE) and changes in the mitochondrial proteome of skeletal muscle with chronic exercise through voluntary wheel running (VWR), time-restricted feeding (TRF), or both combined to boost hepatic KB production and utilization. Control (CON) and HMGCS2 knockout (KO) mice (

Indexed as

Energy MetabolismHydroxymethylglutaryl-CoA SynthaseLiverMitochondrial ProteinsMuscle, SkeletalAnimalsKetone BodiesMaleMiceMice, Inbred C57BLMice, KnockoutPhysical Conditioning, AnimalProteomeProteomicsHMGCS2 protein, mouseHydroxymethylglutaryl-CoA SynthaseKetone BodiesMitochondrial ProteinsProteomeenergy expenditureexerciseHMGCS2ketonesmitochondria

Identifiers

PMID42149693
PMCPMC13290263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.