ArticleJournal of veterinary internal medicine2026
Clinical response of acute idiopathic polyradiculoneuritis treated with therapeutic plasma exchange in four dogs.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Acute idiopathic polyradiculoneuritis (AIP) is an immune-mediated peripheral neuropathy in dogs for which no specific treatment has been established in veterinary medicine. In human medicine, therapeutic plasma exchange (TPE) is a standard treatment for Guillain-Barré syndrome, a clinically analogous condition. In this case series, we describe 4 dogs diagnosed with AIP and treated with TPE. All dogs received 3 consecutive TPE sessions, processing between 4.2 and 4.8 total dog plasma volumes. Motor function improvement was observed after the first session in all cases, with near-complete neurological recovery at discharge. No adverse effects were reported. During follow-up (2-12 months), 3 dogs remained disease-free, and 1 dog experienced a recurrence that subsequently resolved. These cases suggest that TPE might promote rapid clinical improvement in dogs with AIP, representing a promising emergency treatment option for dogs with severe and rapidly progressive neurological deficits.
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