Evidence map›Paper›PMID 42149615›Full record

ArticleApplied and environmental microbiology2026

Global impact on metabolic capacity of yeast cell factories by optogenetic control of the cAMP-PKA axis.

Mohamed Watad, Jonathan Trauth, Filipp Bezold, Ammar Baker, Bastian Pook, Johannes Scheffer, Hagen Nusshär, Sophia Hasenjäger, Nicole Paczia, Lars-Oliver Essen and 1 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohamed WatadUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Jonathan TrauthUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Filipp BezoldUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Ammar BakerUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Bastian PookUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Johannes SchefferUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Hagen NusshärUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
Sophia HasenjägerDepartment of Biology/Genetics, Philipps-University Marburg, Marburg, Germany.
Nicole PacziaMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.
Lars-Oliver EssenUnit for Structural Biochemistry, Department of Chemistry, Philipps-University Marburg, Marburg, Germany.ORCID 0000-0003-4272-4026
Christof TaxisDepartment of Medicine, Health and Medical University Erfurt, Erfurt, Germany.ORCID 0000-0001-5952-7091

Funding

Bundesministerium für Bildung, Wissenschaft und Forschung 031B0358ADeutsche Forschungsgemeinschaft ES152/16-1Deutsche Forschungsgemeinschaft TA320/7-1
6 · The paper itself

Abstract

Dynamic metabolic engineering enables temporal redirection of microbial metabolism from biomass production to product synthesis. Here, we show that optogenetic control of protein kinase A (PKA) activity via light-regulated modulation of intracellular cyclic AMP (cAMP) levels can enhance heterologous production of β-carotene and cordycepin in

Indexed as

Cyclic AMPCyclic AMP-Dependent Protein KinasesOptogeneticsSaccharomyces cerevisiaeAdenylyl Cyclasesbeta CaroteneDeoxyadenosinesMetabolic EngineeringAdenylyl Cyclasesbeta CarotenecordycepinCyclic AMPCyclic AMP-Dependent Protein KinasesDeoxyadenosinesadenylate cyclaseenergy metabolismoptogeneticsproteomicsRas/cAMP/PKA pathway

Identifiers

PMID42149615
PMCPMC13274398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.