Evidence map›Paper›PMID 42149386›Full record

ArticleJournal of neurovirology2026

Morphine potentiates HIV infection and receptor expression in 3d brain organoids.

Michael Swingler, Doga Tasdemir, Senem Cakir, Anna Bellizzi, Martina Donadoni, Ilker K Sariyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael SwinglerDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Doga TasdemirDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Senem CakirDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Anna BellizziDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Martina DonadoniDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Ilker K SariyerDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA. isariyer@temple.edu.

Funding

Gene editing strategies to target HIV for elimination in periphery and brainR01MH110360 · NIMH · DREXEL UNIVERSITY · PI Ilker Kudret Sariyer, Brian Wigdahl · 2016 to 2026
$7.3M
Interdisciplinary And Translational Research Training In NeurohivT32MH079785 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Kamel Khalili · 2008 to 2026
$5.4M
Modulation of OPRM1 alternative splicing by morphine and HIV-1 NefR01DA052284 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI CHANG, SULIE L., SARIYER, ILKER KUDRET · 2021 to 2025
$1.7M
NIDA NIH HHS DA052284NIDA NIH HHS R01 DA052284NIMH NIH HHS MH110360-6NIMH NIH HHS R01 MH110360NIMH NIH HHS T32 MH079785
6 · The paper itself

Abstract

Opioid abuse is a major comorbidity of HIV, yet its direct effects on the brain remain unclear. Using iPSC-derived 3D human cerebral organoids (hCOs), we show that morphine directly upregulates HIV receptors CD4, CCR5, and CXCR4 in the absence of peripheral immune cells or a blood-brain barrier. This receptor induction drives a significant increase in HIV viral load within the CNS, revealing a brain-intrinsic mechanisms of opioid-mediated viral enhancement. These findings establish hCOs as a unique platform to investigate neuroHIV and provide critical insight into how opioids amplify CNS infection independently of peripheral factors.

Indexed as

BrainHIV-1HIV InfectionsMorphineOrganoidsCD4 AntigensHumansInduced Pluripotent Stem CellsReceptors, CCR5Receptors, CXCR4Viral LoadCCR5 protein, humanCD4 AntigensCXCR4 protein, humanMorphineReceptors, CCR5Receptors, CXCR4Cerebral organoidsHIV-1InfectionMorphineOpioidsVirus

Identifiers

PMID42149386
PMCPMC13183757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.