ArticleAnnals of nuclear medicine2026
Whole-brain histogram analysis and top 20% gray and white matter ratio of amyloid positron emission tomography: A comparison with the centiloid scale.
Article in Annals of nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare whole-brain histogram analysis (WBHA) of amyloid-β (Aβ) positron emission tomography (PET) using several magnetic resonance imaging (MRI)-based brain extraction (brain extraction tool [BET]) methods, to evaluate a novel quantitative analysis method, namely the Top 20% Gray and White Matter Ratio (GW-ratio), to determine appropriate thresholds, and to evaluate diagnostic performance in comparison with the Centiloid scale (CL).
methodsWe analyzed structural MRI,
resultsSkewness from three BET methods was strongly negatively correlated with CL. Skewness (HD-BET) showed the strongest correlation (R = -0.9043). Moreover, the GW-ratio strongly correlated with CL (R = 0.8332), whereas MMR, particularly MMR (FSL) (R = 0.2112), showed poor correlation. All indicators significantly distinguished Aβ-negative from Aβ-positive visuals. CL had the highest area under the curve (AUC, 0.9959), followed by skewness (HD-BET) (0.9927), Top 20% GW-ratio (0.9872), and skewness (SPM) (0.9779), with no statistical difference between CL and skewness (HD-BET) (P = 0.5763). Based on mean and SD values from 118 cognitively unimpaired (G-CDR = 0, MMSE ≥ 28) and visually Aβ-negative participants, 95% cut-off limits for Aβ-negative individuals without dementia symptoms were: CL ≤ 12.9, skewness (HD-BET) ≥ 0.1769, MMR (HD-BET) ≤ 0.9372, skewness (FSL) ≥ 0.1819, MMR (FSL) ≤ 1.9132, skewness (SPM) ≥ -0.0382, MMR (SPM) ≤ 1.1274, and GW-ratio ≤ 0.1079.
conclusionWBHA using MRI-based BET and GW-ratio showed strong correlations with CL and demonstrated a diagnostic performance comparable to that of CL.
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