ArticleClinical and experimental nephrology2026
Renal function and comprehensive frailty in community-dwelling older adults: cross-sectional and longitudinal analyses.
Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic kidney disease is common older adults, yet its role in overall frailty remains unclear, particularly when assessed using the Questionnaire for Medical Checkup of Old-Old (QMCOO). This study investigated both cross-sectional and longitudinal links between renal function and multidomain frailty in community-dwelling older adults.
methodsWe analyzed data from 4621 participants (mean age: 80.1 years; men:39.5%) who underwent health checkups in Nobeoka City, Japan (April 2020 to March 2021). Renal function was assessed using estimated glomerular filtration rate (eGFR) and grouped as ≥ 60, 45-59, 30-44, and < 30 mL/min/1.73 m
resultsFrailty prevalence increased as renal function declined (21.5%, 23.2%, 32.8%, and 38.7% across eGFR groups). Similar patterns were observed for physical, oral, nutritional, and cognitive domains, but not for social frailty. Over 1 year, participants with eGFR < 30 had a higher risk of developing frailty than those with eGFR ≥ 60 (adjusted odds ratio 2.37; 95% confidence interval [CI] 1.10-5.20).
conclusionsDeclined kidney function was independently associated with both higher prevalence and incidence of comprehensive frailty, particularly in physical, oral, nutritional, and cognitive domains. Preserving renal function may help reduce frailty risk in older adults.
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