ArticleFolia microbiologica2026
Exploring the anticancer potential of Streptomyces sp. M4 extract: effects on apoptosis in gastric cancer ags cells.
Article in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gastric cancer is a leading cause of cancer-related mortality worldwide, emphasizing the need for novel therapeutic strategies. Actinobacteria are prolific producers of bioactive secondary metabolites with anticancer potential. In this study, we evaluated the antitumor activity of Streptomyces sp. M4 extract against the human gastric adenocarcinoma (AGS) cell line and explored its underlying mechanisms. The strain was cultured in starch casein broth, and metabolites were extracted using ethyl acetate. AGS cell were treated with the crude extract, and cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while apoptosis was analyzed by flow cytometry. Gene expression was measured using real-time PCR, and Caspase-3/7 activity was determined via colorimetric assays. The MTT assay revealed potent cytotoxicity with an IC
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