Evidence map›Paper›PMID 42149288›Full record

ReviewGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Tackling similarities and differences in global practice guidelines for gastric cancer: a review on the latest Taiwan guidelines with Asia-Pacific, European and US guidelines.

Chih-Chieh Yen, I-Chen Wu, Cheng-Chan Yu, Ming-Huang Chen, Nai-Jung Chiang, Wen-Liang Fang, Kuo-Hsing Chen, Chieh-Chang Chen, Tzu-Chan Hong, Yen-Cheng Chen and 21 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomarker discordance in gastric cancer: from tissue snapshots to treatment-defining assays.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Chih-Chieh Yen *Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
I-Chen Wu *Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cheng-Chan Yu *Division of General Surgery, Department of Surgery, Taichung Tzu Chi Hospital, Taichung, Taiwan.
Ming-Huang ChenDepartment of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
Nai-Jung ChiangDepartment of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.
Wen-Liang FangDepartment of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Kuo-Hsing ChenDepartment of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.
Chieh-Chang ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Tzu-Chan HongDepartment of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
Yen-Cheng ChenDivision of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Hualien, Taiwan.
Ming-Wun WongDepartment of Medicine, Hualien Tzu Chi Hospital, Hualien, Taiwan.
De-Chuan ChanDivision of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan.
I-Shu ChenDivision of General Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Yen-Yang ChenDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Yueh-Wei LiuDivision of General Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Jiann-Ming WuDivision of General Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Wen-Chi ChouDepartment of Hematology and Oncology, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chan-Keng YangDepartment of Hematology and Oncology, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jun-Te HsuDepartment of General Surgery, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ta-Sen YehDepartment of General Surgery, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Li-Yuan BaiDepartment of Hematology and Oncology, China Medical University Hospital, Taichung, Taiwan.
Yi-Fang ChangDivision of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Yao-Yu HsiehDivision of Hematology and Oncology, Department of Medicine, Taipei Medical University Shuang-Ho Hospital, New Taipei City, Taiwan.
Cheng-Ming PengDepartment of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan.
Jaw-Yuan WangDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Hui-Hua HsiaoDivision of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Li-Tzong ChenDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kun-Ming RauDepartment of Hematology Oncology, E-Da Cancer Hospital, Kaohsiung, Taiwan.
Chia-Jui YenDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jen-Shi ChenDepartment of Hematology and Oncology, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yan-Shen ShanDepartment of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. ysshan@mail.ncku.edu.tw.ORCID 0000-0002-2457-5189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) remains a global health burden. While international guidelines share consensus, variations exist in disputed issues. The 2025 Taiwan Consensus and Management Guidelines for Gastric Cancer had just been released. We compared the key recommendations with established international guidelines.

methodsA multidisciplinary taskforce addressed key questions and recommendations using modified Delphi method and evidence-based approaches. The comparative review aimed to elucidate similarities and differences among guidelines from Taiwan, Japan, South Korea, China, Europe, and the US.

resultsGuidelines converge on absolute endoscopic resection criteria for early GC but differ in extended indications and perioperative approaches for locally advanced disease. Heterogeneity exists in biomarker assessment protocols, cutoff thresholds, and companion diagnostics. For metastatic disease, consensus exists on anti-HER2, anti-VEGF, immunotherapy, and biomarker-driven strategies, though oligo-metastatic definitions and intraperitoneal chemotherapy indications remain controversial.

conclusionOptimal GC management requires integrating global evidence with regional contexts. The comparative review addresses heterogeneity among international guidelines, which helps harmonize management strategies as therapeutic standards evolve.

Indexed as

Practice Guidelines as TopicStomach NeoplasmsAsiaBiomarkers, TumorEuropeHumansTaiwanUnited StatesBiomarkers, TumorBiomarkerConsensusGastric cancerGuidelinesManagement

Identifiers

PMID42149288
PMCPMC13315491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.