ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Ocular clinical characteristics and surgical outcomes of patients with stickler syndrome.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeStickler syndrome represents a group of rare, inherited genetic disorders and is the leading cause of inherited retinal detachment (RD). This study aimed to examine the ocular clinical characteristics and compare the surgical outcomes of Stickler syndrome.
methodsThis single-center, retrospective study included 86 patients diagnosed with Stickler syndrome (58 genetically confirmed) between 2012 and 2024. Patients with RD underwent one of two surgical procedures, and their anatomical and functional outcomes were compared. Patients without RD underwent ora serrata and peripheral retinal screening, with 360° prophylactic laser therapy applied to high-risk eyes exhibiting pathology.
resultsThe pars plana vitrectomy (PPV) group exhibited more severe baseline clinical characteristics than the scleral buckle (SB) group. After surgery, the two groups showed no statistically significant differences in any outcomes except anatomical success rate and best-corrected visual acuity (BCVA). Preoperative BCVA, the presence of cataract, RD extent and status, proliferative vitreoretinopathy (PVR) grade, and silicone oil tamponade were significantly associated with worse postoperative BCVA. Patients at high risk of RD underwent ora serrata and peripheral retina screening, and 36 eyes received prophylactic laser treatment. Preoperative retinal breaks and ora serrata dialysis were independent risk factors for post-laser RD.
conclusionStickler syndrome is a progressive disorder associated with a high risk of RD. Early diagnosis and regular surveillance are crucial for initiating timely intervention. Further research is needed to understand the pathogenesis of Stickler syndrome better, develop more effective prophylactic and surgical strategies, and improve outcomes for affected individuals.
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