SynthesisLangenbeck's archives of surgery2026
Postoperative outcomes in CNS WHO grade 2 and 3 meningioma: a systematic review and meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Distinct clinical characteristics and prognostic factors of pediatric meningiomas in a 10-year cohort of 198 patients.Neurosurgical review · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWHO grade 2 and 3 meningiomas account for approximately 20% of all meningiomas. The relatively lower incidence has resulted in limited representation of clinical outcomes in the literature, with only broad estimates of postoperative prognosis currently available. This study aimed to establish pooled incidence of recurrence and 5-year progression-free survival (PFS) and overall survival (OS) rates for grade 2 and 3 meningiomas.
methodsA PRISMA-compliant systematic review was prospectively registered (PROSPERO CRD42023441009). MEDLINE, EMBASE, and the Cochrane Library were searched from inception to September 2023. Eligible studies enrolled adults (≥ 16 years) with histologically confirmed WHO grade 2 or 3 cranial meningiomas who underwent surgery with or without adjuvant radiotherapy and/or stereotactic radiosurgery. The primary outcome was pooled annual incidence of recurrence; secondary outcomes were pooled 5-year PFS and OS, estimated using random-effects models.
resultsSeventy-four studies met inclusion criteria (68 reporting on grade 2, 22 on grade 3 meningiomas), comprising 4,937 grade 2 and 253 grade 3 patients. The pooled annual incidence of recurrence was 6% (95% CI: 5-7%; I
conclusionThis systematic review and meta-analysis provides pooled estimates of recurrence rate, 5-year PFS, and 5-year OS for WHO grade 2 and 3 meningiomas. Interpretation is constrained by the predominantly retrospective design of included studies and considerable clinical heterogeneity across the pooled cohorts.
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