Evidence map›Paper›PMID 42148836›Full record

ArticleJournal of the American Chemical Society2026

A Synthetic Molybdenum Hydroxylase Compound That Cleaves C-H Bonds by Hydride Abstraction.

Ananthu V Modappilappally, Neal P Mankad

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ananthu V ModappilappallyDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Neal P MankadDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0001-6923-5164

Funding

Multimetallic Catalysis in Biology and SynthesisR35GM140850 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MANKAD, NEAL P · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM140850
6 · The paper itself

Abstract

Molybdenum-dependent hydroxylases catalyze site-selective C-H hydroxylation reactions involving hydride abstraction pathways, yet no synthetic system has previously reproduced this reactivity. Here, we report a synthetic molybdenum hydroxylase that achieves C-H bond cleavage and hydroxylation through a bioinspired H

Identifiers

PMID42148836
PMCPMC13222537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.