Evidence map›Paper›PMID 42148822›Full record

SynthesisJournal of the American Medical Informatics Association : JAMIA2026

Alert fatigue measurement in clinical decision support: a systematic review.

Cara E Ray, Geneva M Wilson, Ashley M Hughes, Cassie Cunningham Goedken, Eric Ping-Fei Liu, Margaret A Fitzpatrick, Katie J Suda, Satya Manasa Kota, Chinonyerem Nwankpa, Charlesnika T Evans

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Medical Informatics Association : JAMIA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cara E RayCenter of Innovation for Complex Chronic Healthcare, Edward Hines Jr. VA Medical Center, United States Department of Veterans Affairs, Hines, Illinois, United States.ORCID 0000-0002-1383-8801
Geneva M WilsonCenter of Innovation for Complex Chronic Healthcare, Edward Hines Jr. VA Medical Center, United States Department of Veterans Affairs, Hines, Illinois, United States.
Ashley M HughesCenter of Innovation for Complex Chronic Healthcare, Edward Hines Jr. VA Medical Center, United States Department of Veterans Affairs, Hines, Illinois, United States.ORCID 0000-0002-1431-3396
Cassie Cunningham GoedkenCenter for Access & Delivery Research and Evaluation, Iowa City VA Health Care System, United States Department of Veterans Affairs, Iowa City, Iowa, United States.
Eric Ping-Fei LiuDepartment of Preventive Medicine, Center for Health Services and Outcomes Research, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Margaret A FitzpatrickSeattle-Denver Center of Innovation for Veteran-Centered and Value-Driven Care, VA Eastern Colorado Healthcare System, United States Department of Veterans Affairs, Aurora, Colorado, United States.
Katie J SudaCenter for Healthcare Evaluation, Research, and Promotion, VA Pittsburgh Healthcare System, United States Department of Veterans Affairs, Pittsburgh, Pennsylvania, United States.
Satya Manasa KotaDepartment of Epidemiology and Biostatistics, University of Illinois Chicago School of Public Health, Chicago, Illinois, United States.ORCID 0009-0008-2490-9143
Chinonyerem NwankpaDepartment of Biology, North Carolina A&T State University College of Science & Technology, Greensboro, North Carolina, United States.
Charlesnika T EvansCenter of Innovation for Complex Chronic Healthcare, Edward Hines Jr. VA Medical Center, United States Department of Veterans Affairs, Hines, Illinois, United States.

Funding

Department of Veterans Affairs Health Services Research & DevelopmentDepartment of Veterans Affairs Health Services Research & Development (HSR&D) Small Award Initiative for Impact program, Center of Innovation for Complex Chronic Healthcare # SWC 24-004 (Principal Investigator: C.E.R.)HSR&D Senior Research Career Scientist # MRA0-001-24W (Principal Investigator: C.T.E)HSRD VA I50 HX003230HSRD VA IK6 HX003156Quality Enhancement Research Initiative program # QUE 20-016 (Principal Investigator: C.T.E.)
6 · The paper itself

Abstract

backgroundAlert fatigue is defined as alert dismissals due to excessive or irrelevant alerts and is frequently cited as a barrier to clinical decision support system use and impact. However, the criteria for determining the presence or absence of alert fatigue are poorly defined. The objective of this systematic review of systematic reviews was to identify operationalized definitions and measures of alert fatigue or alert-related metrics.

methodsSystematic reviews reporting at least one alert-related metric or measure/operationalization of alert fatigue for physician-directed electronic alerts were included. The Cochrane Library, Embase, and PubMed were searched from database start to 2024. The Revised Assessment of Multiple Systematic Reviews was used to assess study quality and risk of bias. Data were synthesized narratively and with descriptive statistics.

resultsA total of 22 studies were included in the review. Studies reported between 1 and 11 alert metrics. Studies were most often of medium quality. Reporting of primary study characteristics was frequently judged to be insufficient. Only one article reported an operational definition of alert fatigue. The most common alert metrics were quantity, override rate, and acceptance rate. DISCUSSION: Alert fatigue measurement methods are not clearly or consistently defined in systematic reviews related to alert fatigue in clinical decision support. Reporting of other primary study characteristics is often limited. We recommend that future efforts use a significant, sustained decrease in appropriate alert response rates from an established baseline as a measure of alert fatigue.

Indexed as

Alert Fatigue, Health PersonnelDecision Support Systems, ClinicalHumansalert fatigueclinicaldecision support systemshealth care evaluation mechanismshealth personnelmedical informaticssensitivity and specificity

Identifiers

PMID42148822
PMCPMC13385993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.