Evidence map›Paper›PMID 42148817›Full record

ArticleFEMS microbiology letters2026

Identification of interbacterial adhesion between oral Schaalia species and streptococcal serine-rich repeat glycoproteins.

Christian P Ahearn, Hervé Tettelin, M Margaret Vickerman, Stefan Ruhl

Abstract read
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In one paragraph

Article in FEMS microbiology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian P AhearnDepartment of Oral Biology, University at Buffalo School of Dental Medicine, Buffalo, NY 14214-8024, United States.ORCID 0000-0003-1865-5868
Hervé TettelinDepartment of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
M Margaret VickermanDepartment of Oral Biology, University at Buffalo School of Dental Medicine, Buffalo, NY 14214-8024, United States.
Stefan RuhlDepartment of Oral Biology, University at Buffalo School of Dental Medicine, Buffalo, NY 14214-8024, United States.ORCID 0000-0003-3888-4908

Funding

Microbial Recognition of Sialic Acid Diversity in the Salivary ProteomeR01DE019807 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUHL, STEFAN HANS-KLAUS · 2010 to 2022
$4.7M
Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
HARNESSING THE ORAL MICROBIOME TO CREATE NOVEL GLYCAN-BINDING PROBESU01CA221244 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUHL, STEFAN HANS-KLAUS, SULLAM, PAUL M. · 2017 to 2019
$1.4M
MINING THE ORAL MICROBIOME FOR NOVEL GLYCAN-BINDING MOLECULESR21DE025826 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUHL, STEFAN HANS-KLAUS, SULLAM, PAUL M. · 2015 to 2016
$638k
Sialic acid mediated interbacterial adhesion among oral bacteriaF32DE031963 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI AHEARN, CHRISTIAN · 2022 to 2022
$71k
NCI NIH HHS U01 CA221244NIDCR NIH HHS F32 DE031963NIDCR NIH HHS R01 DE019807NIDCR NIH HHS R21 DE025826NIDCR NIH HHS T32 DE023526
6 · The paper itself

Abstract

Interbacterial adhesion is central to multispecies biofilm formation. Streptococcal serine-rich repeat glycoproteins (SRRPs) play a well-defined role in oral colonization, yet SRRP involvement in interbacterial adhesion remains understudied. Here, we aimed to isolate SRRP-dependent adhesion partners of Streptococcus gordonii Challis (DL1) from human oral microbiota. Of 179 isolates screened, 23 coaggregated with DL1 but not with an isogenic SRRP-encoding gene deletion mutant. Whole-genome sequencing identified isolates as 19 Schaalia odontolytica, 3 Schaalia sp. HMT-172, and 1 non-Schaalia mixed-species isolate. Each Schaalia isolate also coaggregated with other oral streptococcal species that encoded SRRPs. When Sch. spp. whole cells were probed with a recombinant DL1 SRRP binding domain, which binds to sialic acids, no binding was observed. Formaldehyde and heat treatment of Sch. spp. cells to denature surface proteins reduced coaggregation with DL1 cells, whereas the same treatment of DL1 did not affect coaggregation with Sch. spp. Proteinase K treatment of DL1 or Sch. spp. reduced or eliminated coaggregation, respectively. Based on these observations, we propose that Sch. odontolytica and Sch. sp. HMT-172 surface proteins bind to formaldehyde- and heat-stable epitopes of streptococcal SRRPs, potentially constituting an important interbacterial adhesion interaction in oral biofilm formation.

Indexed as

Bacterial AdhesionBacterial ProteinsGlycoproteinsMouthStreptococcusAdhesins, BacterialBiofilmsHumansStreptococcus gordoniiAdhesins, BacterialBacterial ProteinsGlycoproteinscoaggregationinterbacterial adhesionoral streptococciSchaalia odontolyticaSchaalia sp. HMT-172serine-rich repeat glycoprotein (SRRP)

Identifiers

PMID42148817
PMCPMC13249566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.