ArticleAnnals of medicine2026
A cohort study on inflammatory response and coagulation function changes in women with silver clip or silk ligation sterilisation.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
backgroundTo investigate the long-term systemic effects of tubal sterilisation using the silver clip technique, a commonly used yet understudied permanent contraceptive method, by evaluating its impact on inflammatory responses and coagulation function. DISCUSSION: A multicentre ambispective cohort study will be conducted in ten hospitals. Women with a history of silver clip sterilisation, silk ligation, or condom contraception who require surgical management for benign gynaecological diseases will be recruited. Participants will be followed up at 1 day, 1 month, 6 months, and 12 months postoperatively. Key measurements will include serum silver concentrations (
conclusionsThis study will provide evidence to support long-term safety monitoring of silver levels in women who have undergone silver clip sterilisation. It may increase awareness of potential health concerns, including inflammation and coagulation abnormalities. The findings may also contribute to the development of updated contraceptive guidelines for policymakers and women of childbearing age.
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