Evidence map›Paper›PMID 42148519›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Rumination syndrome and eosinophilic esophagitis in children: Defining the relationship.

Dennis Yang, Peter L Lu, Janice S Khoo, Raul E Sanchez, Rajitha D Venkatesh, John M Russo, Neetu Bali, Karla Vaz, Desale Yacob, Carlo Di Lorenzo and 1 more

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Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Dennis YangDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Peter L LuDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Janice S KhooDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Raul E SanchezDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Rajitha D VenkateshDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
John M RussoDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Neetu BaliDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Karla VazDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Desale YacobDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Carlo Di LorenzoDepartment of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.
Ashley M Kroon Van DiestDepartment of Pediatric Psychology and Neuropsychology, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID https://orcid.org/0009-0002-2118-7727

Funding

None
6 · The paper itself

Abstract

objectivesWhile rumination syndrome (RS) and eosinophilic esophagitis (EoE) can share overlapping symptoms, their association remains unclear. Our objective was to explore the relationship between RS and EoE and understand the clinical course of children with both conditions.

methodsWe conducted a retrospective cohort study of children with RS and EoE evaluated at our institution from 2016 to 2023. Patient characteristics, symptoms, treatments, and outcomes were compared.

resultsAmong 230 children with RS, 22 (10%) had both RS and EoE (77% male, median age 18 years). Sixteen (70%) were first diagnosed with EoE, two (9%) with RS, and four (18%) concurrently. Most (91%) presented with regurgitation; 64% reported dysphagia at some point. EoE treatment led to mucosal remission in 73% and improved dysphagia in 41%, but 86% continued to experience regurgitation. RS treatment, including behavioral therapy and baclofen, improved or resolved regurgitation in 64%. Peak eosinophil counts were similar in children with and without dysphagia (43 vs. 51 eos/HPF, p = 0.589). Those without dysphagia responded better to RS treatment (67% vs. 22%), though the difference was not statistically significant. Among those diagnosed with EoE first, RS diagnosis occurred after a median of 15.4 months.

conclusionsEoE was more prevalent among children with RS than in the general population. Regurgitation seemed more responsive to RS treatment than EoE treatment. In patients with EoE and persistent regurgitation, RS should be considered, especially when symptoms persist despite EoE remission.

Indexed as

Eosinophilic EsophagitisRumination SyndromeAdolescentChildChild, PreschoolDeglutition DisordersFemaleHumansMaleRetrospective Studiesdysphagiapediatricsregurgitation

Identifiers

PMID42148519
PMCPMC13539637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.