Evidence map›Paper›PMID 42148429›Full record

ArticleBJUI compass2026

Time toxicity of intravesical BCG versus sequential intravesical gemcitabine and docetaxel for non-muscle-invasive bladder cancer.

Jacob Hanna, Melinda Z Fu, Berk Inan, David Guevara, Lucille Lannan, Disha Patel, Mahdi Hemmati Ghavshough, David Golombos, Thomas Jang, Saum Ghodoussipour and 1 more

Abstract read
In one paragraph

Article in BJUI compass, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Round up.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jacob HannaRutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.ORCID https://orcid.org/0009-0009-1622-8230
Melinda Z FuSection of Urologic Oncology Rutgers Cancer Institute New Brunswick New Jersey USA.
Berk InanRutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.
David GuevaraRutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.ORCID https://orcid.org/0009-0006-0178-4590
Lucille LannanRutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.
Disha PatelSection of Urologic Oncology Rutgers Cancer Institute New Brunswick New Jersey USA.
Mahdi Hemmati GhavshoughSection of Urologic Oncology Rutgers Cancer Institute New Brunswick New Jersey USA.
David GolombosSection of Urologic Oncology Rutgers Cancer Institute New Brunswick New Jersey USA.
Thomas JangSection of Urologic Oncology Rutgers Cancer Institute New Brunswick New Jersey USA.ORCID https://orcid.org/0000-0001-5886-3835
Saum GhodoussipourRutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.
Vignesh T PackiamRutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA.

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
NCI NIH HHS P30 CA072720
6 · The paper itself

Abstract

Objectives: This study aimed to evaluate the time toxicity of intravesical BCG compared to sequential intravesical gemcitabine and docetaxel (Gem/Doce) for non-muscle-invasive bladder cancer (NMIBC). Patients and Methods: After IRB approval, we retrospectively reviewed patients with NMIBC treated with BCG or Gem/Doce between 2022 and 2025 at our institution. Medical records were used to calculate time for intravesical therapy, office visits, transurethral resection of bladder tumour (TURBT) and emergency department encounters. Continuous variables were compared using the Wilcoxon rank sum test with Hodges-Lehmann estimates. Results: Of 133 patients, 86 received BCG (65%) and 47 Gem/Doce (35%). Patients with BCG were more likely treatment naïve compared to those with Gem/Doce (77% vs 55%, Conclusion: Gem/Doce requires a greater time investment than BCG. As effective NMIBC therapies expand, time toxicity should be considered alongside oncologic outcomes.

Indexed as

BCGbladder cancerdocetaxelgemcitabineintravesical therapynon–muscle‐invasive bladder cancertime toxicity

Identifiers

PMID42148429
PMCPMC13173358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.