Trial reportDrug design, development and therapy2026
Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Response to "Methodological Caveats in Evaluating Perioperative Esketamine for Postoperative Pain Sensitivity: A Comment on the Study by Chen et al" [Response to Letter].Drug design, development and therapy · 2026Article
- Methodological Caveats in Evaluating Perioperative Esketamine for Postoperative Pain Sensitivity: A Comment on the Study by Chen et al [Letter].Drug design, development and therapy · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Postoperative pain sensitivity is a key target for perioperative analgesic care, linked to acute severe pain and chronic pain risk. This study aimed to investigate whether perioperative subanesthetic esketamine attenuates early postoperative pain sensitivity in patients undergoing emergency laparoscopic salpingectomy for ectopic pregnancy. Methods: This randomized controlled trial enrolled patients with ectopic pregnancy undergoing laparoscopic salpingectomy, randomly assigned 1:1 to esketamine or control. Patients in the esketamine group received an intravenous bolus of esketamine 0.25 mg/kg during surgery, followed by a patient-controlled intravenous analgesia (PCIA) solution containing esketamine (1 mg/kg) and sufentanil (1 μg/kg). The control group received a PCIA solution containing a higher dose of sufentanil (2 μg/kg) with equivalent volumes of normal saline instead of esketamine. The primary outcome was postoperative pain sensitivity, assessed by the Pain Sensitivity Questionnaire (PSQ) at postoperative day 1, 2, and 7. Secondary outcomes included the Numeric Rating Scale (NRS) pain scores, the 17-item Hamilton Depression Rating Scale (HAMD-17) scores, serum prostaglandin E2 (PGE2), brain-derived neurotrophic factor (BDNF) levels, and adverse events. Results: A total of 84 patients were enrolled and randomized (42 per group), with 80 completing the trial (42 in the esketamine group, 38 in the control group). For the primary outcome, repeated-measures ANOVA revealed a significant main effect of group on PSQ-total scores (F(1,78) = 9.881, Conclusion: Perioperative subanesthetic esketamine may provide modest improvement in early postoperative pain sensitivity, and may serve as a useful adjunct in multimodal postoperative analgesia for emergency laparoscopic salpingectomy.
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