Evidence map›Paper›PMID 42148153›Full record

ReviewFrontiers in molecular biosciences2026

RNA duplex formation and competing endogenous RNA, proposed as mechanisms in regulating expression of natural antisense transcripts- from hypotheses to potential therapeutic applications.

Richi Nakatake, Tetsuya Okuyama, Tominori Kimura, Mikio Nishizawa

Abstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Richi NakatakeDepartment of Pancreatobiliary Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Tetsuya OkuyamaDepartment of Pancreatobiliary Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Tominori KimuraComprehensive Research Organization for Science and Society, Ritsumeikan University, Kusatsu, Shiga, Japan.
Mikio NishizawaCollege of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural antisense transcripts (NATs) from eukaryotic genes, known as long non-coding RNAs (lncRNAs), are long transcripts that do not encode proteins. NATs play diverse functional roles in regulating the transcription, stability, and translation of protein-coding genes at the epigenetic and post-transcriptional levels. Here, we outline recent studies on NAT-mediated RNA networks and discuss their potential as therapeutic targets across diseases. Interferon-α1 (

Indexed as

circular RNAcompeting endogenous RNAextracellular vesiclemethyladenosinemiRNAnatural antisense transcriptnon-coding RNAoligonucleotide

Identifiers

PMID42148153
PMCPMC13171403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.