ArticleFrontiers in immunology2026
A
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Introduction: Methods: Pigs received two intramuscular (IM) or two intradermal (ID) doses and adaptive immune responses were assessed weekly by three-color FluoroSpot assays, multi-parameter flow cytometry and anti-CPAF ELISAs. Results: Among the vaccine candidates tested, the novel CPAF-STG1151 conjugate elicited the strongest systemic T cell response. It induced a robust cell-mediated immune response characterized by IFNγ production with or without TNFα coproduction and this response was equally mediated by all T cell subsets (CD4, CD8 and γδ T cells). The route of administration (IM vs. ID) had no significant effect on either the magnitude or the cytokine profile of the cell-mediated immune response. The highest anti-CPAF IgG serum levels were also observed following vaccination with the CPAF-STG1151 conjugate vaccine candidate. Discussion: Thus, conjugation of the STING pathway agonist STG1151 to the Chlamydia protein CPAF resulted in a highly immunogenic subunit vaccine. Future studies will determine mucosal administration routes and assess the vaccine efficacy of this promising Ct vaccine candidate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.