ArticleFrontiers in immunology2026
Preclinical evaluation of a bivalent conjugate vaccine against
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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16 authors.
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Abstract
Introduction: Methods: To create the bivalent vaccine, the Results: The newly developed bivalent vaccine was stable over time, when stored at 2-8 °C. A slight increase of free O:2 was detected, but remained below 15% after 1 year of storage. In preclinical models, the bivalent formulation elicited strong immune responses against both antigens, higher than the corresponding unconjugated polysaccharides. These results have guided the selection of the formulations to be tested in clinical studies. Conclusions: This vaccine has the potential to broaden protection against enteric fever, particularly in high-incidence regions. Further clinical trials are ongoing to confirm efficacy and safety in humans.
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