ArticleFrontiers in immunology2026
Analysis of the predictive value of Th17/Treg cells and cytokines for the risk of infection after kidney transplantation.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to analyze the factors associated with infection after kidney transplantation and to explore the predictive value of Th17/Treg cells and cytokine levels for infection. Methods: A retrospective analysis was conducted on 200 patients who underwent kidney transplantation between May 2021 and January 2024. Patients were divided into an infection-free group (70 cases) and an infection group (130 cases) based on infection status within 1 year post-surgery. General clinical data were collected, and changes in Th17 and Treg cell ratios were detected using flow cytometry. Cytokine levels, including IL-17, IL-22, IL-10, and TGF-β, were measured using an enzyme-linked immunosorbent assay (ELISA) kit. Patients were divided into high- and low-expression groups based on the median serum Th17/Treg cell and cytokine levels, and the incidence of infection after kidney transplantation was compared between the two groups. Logistic regression analysis was used to identify independent risk factors for infection after kidney transplantation. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of Th17/Treg cell and cytokine levels for infection after kidney transplantation. Results: The infection group had a higher age and a higher proportion of preoperative hemodialysis compared to the non-infection group (p < 0.05). The infection group had higher Th17 cell proportions, Th17/Treg ratios, and serum IL-17 and IL-22 levels compared to the non-infection group, while the Treg cell proportions and serum IL-10 and TGF-β levels were lower in the infection group compared to the non-infection group (p < 0.001). High expression of Th17 cells and pro-inflammatory cytokines (IL-17 and IL-22) was associated with an increased risk of infection, while high expression of Treg cells and anti-inflammatory cytokines (IL-10 and TGF-β) was associated with a reduced risk of infection. Multivariate logistic regression analysis indicated that preoperative hemodialysis, elevated Th17/Treg ratio, elevated IL-17 and IL-22 levels, and reduced IL-10 and TGF-β levels were independent risk factors for infection after kidney transplantation (p < 0.05). ROC curve analysis indicated that the aforementioned indicators had high predictive value for infection within 1 year post-surgery, with the Area Under the Curve (AUC) of the Th17/Treg ratio reaching 0.927. Conclusion: Patients with post-transplant infections exhibit a significant Th17/Treg cell imbalance. Elevated Th17/Treg ratios, increased IL-17 and IL-22 levels, and decreased IL-10 and TGF-β levels are independent risk factors for post-transplant infections. These indicators also have high predictive value for post-transplant infection risk and may serve as potential biomarkers for early clinical assessment of infection risk.
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