ArticleProceedings (Baylor University. Medical Center)2026
Disaccharidase testing and clinical outcomes: a retrospective study.
Article in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Disaccharidase testing in adults: do we need new testing standards?Proceedings (Baylor University. Medical Center) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The etiology of many common gastrointestinal symptoms such as abdominal pain, diarrhea, and bloating often remains elusive despite laboratory and endoscopic evaluation. Disaccharidase deficiency is often overlooked as a cause of these symptoms. Our retrospective cohort study aimed to assess the potential of disaccharidase testing in guiding treatment strategies and improving clinical outcomes in adults presenting with unexplained gastrointestinal symptoms. Methods: A retrospective cohort study was conducted using records from Westchester Medical Center Health system from February 2023 through May 2024. We reviewed records of symptomatic adult patients who underwent diagnostic esophagogastroduodenoscopy and biopsy for disaccharidase testing. Exclusion criteria included patients with pancreatitis, inflammatory bowel disease, and celiac disease. Fisher's exact test was used to determine the association between interventions and symptom improvement. Results: A total of 78 patients who underwent disaccharidase testing were identified, of whom 11 met the exclusion criteria. Of the 67 remaining, 88.1% had at least one deficiency. Abnormal disaccharidase results were stratified into those with single deficiencies (74.6%), pan-disaccharidase deficiencies (11.9%), and >1 enzyme deficiencies (13.6%). Among those with abnormal disaccharidase testing results (59 patients), 57 received interventions. There was a significant association between interventions and symptom improvement ( Conclusion: Our study demonstrates a statistically significant association between targeted treatment strategies and symptom improvement in patients with identified disaccharidase deficiencies. Given the high prevalence of disaccharidase deficiencies and their symptomatic overlap with conditions such as inflammatory bowel disease, there is a potential benefit for routine disaccharidase testing during esophagogastroduodenoscopy in patients with unexplained gastrointestinal symptoms.
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