ArticleQuantitative imaging in medicine and surgery2026
Clinical application of a full free-breathing cardiac MRI protocol: feasibility, efficiency, and diagnostic accuracy.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Conventional cardiac magnetic resonance imaging (MRI) protocols require multiple breath-holds (BHs) for each sequence, limiting their widespread clinical application. This study sought to develop a full free-breathing (FB) cardiac MRI protocol, including cine imaging, T2 weighted imaging (T2WI), and late gadolinium enhancement (LGE) imaging, and to assess its clinical feasibility. Methods: A total of 94 patients who underwent paired BH- and FB-acquired cine imaging, T2WI, and LGE imaging at 3.0T were prospectively included in the study. The primary analysis included image quality (IQ), qualitative assessment of myocardial edema and enhancement, and quantification of biventricular function and LGE. The overall IQ of all sequences was visually evaluated using a five-point Likert scale. Blood to myocardial contrast (BMC) was measured to quantitatively evaluate the IQ of the short-axis cine sequence. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated to evaluate the IQ of the T2WI and LGE sequences. Function parameters, including left ventricular ejection fraction (LVEF) and right ventricular ejection fraction (RVEF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and left ventricular (LV) mass, were measured and compared. Results: The proposed full FB protocol achieved identical diagnoses in all patients. The total scan time of all FB sequences was significantly shorter than that of all BH sequences (551±194 Conclusions: A FB cardiac MRI protocol is feasible in clinical practice, providing shorter acquisition times, comparable IQ, and highly accurate qualitative and quantitative results.
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