ArticleQuantitative imaging in medicine and surgery2026
The impacts of time of echo and time of repetition on slow diffusion coefficient (SDC) measure and the potential age- and gender-related variations in liver and spleen SDC values: studies of healthy volunteers.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Relationships among slow diffusion coefficient and diffusion-derived 'vessel density' signal features, Gadoxetate delayed enhancement, tumor size, tumor grading, and patient survival: an exploratory study of mass-forming intrahepatic cholangiocarcinoma.Journal of gastrointestinal oncology · 2026Article
- Classification of hepatocellular carcinoma Ki-67 expression status by a simple combination of magnetic resonance slow diffusion coefficient (SDC) and apparent diffusion coefficient (ADC): initial promising results.Quantitative imaging in medicine and surgery · 2026Article
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Abstract
Background: The time of echo (TE) and time of repetition (TR) impact the apparent diffusion coefficient (ADC) value. This study investigates the impact of TE and TR on slow diffusion coefficient (SDC) values of the liver and spleen. An age-related decline of liver ADC has been described for both men and women. However, a lower perfusion level, a higher fat level and a higher iron level can all lead to a decrease in liver ADC value in older populations. This study also investigates whether there is an age-related decrease in the liver slow diffusion as measured by SDC. Methods: For dataset 1, liver and spleen diffusion weighted imaging (DWI) data was acquired at 3.0 T with six young healthy volunteers totaling 23 scans, and Results: Dataset 1 showed, following the increase in TE from 46 to 80 ms, SDC decreased by 63.9% (median) for the liver and by 31.0% (median) for the spleen, and SDC Conclusions: The TE and TR have very notable impacts on SDC values. There may be no true tissue diffusion change following aging for men and women. The difference in liver SDC between pre-menopausal women value and post-menopausal women value suggest that iron-related T2* shortening lead to a lower SDC measure. SDC may be insensitive to tissue perfusion and liver fat signal.
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