ArticleQuantitative imaging in medicine and surgery2026
Three-dimensional assessment of posterior polymorphous corneal dystrophy with swept-source optical coherence tomography.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Posterior polymorphous corneal dystrophy (PPCD), also known as Schlichting dystrophy, can present as either autosomal dominant or isolated unilateral cases, with a similar phenotype but without a hereditary pattern. This study aimed to investigate the characteristics of PPCD using wide-field, high-resolution, swept-source optical coherence tomography (SS-OCT). Methods: We retrospectively reviewed 16 eyes of 10 patients with PPCD, all of whom exhibited typical slit-lamp biomicroscopic and in vivo confocal microscopy (IVCM) findings, including endothelial vesicular, placoid, and/or band-like pathological changes. All participants underwent a comprehensive ophthalmological assessment, including anterior segment imaging, corneal endothelial specular microscopy, and IVCM. Wide-field SS-OCT was performed on the cornea, and the cornea's posterior surface was then individually visualized and analyzed. Results: In total, 16 eyes of 10 patients (six females and four males), aged 9 to 30 years, were included in this study. The wide-field Conclusions: Non-invasive wide-field SS-OCT can clearly identify characteristic microstructural alterations at the level of the whole posterior corneal surface in PPCD, and may aid in the diagnosis and follow-up of PPCD.
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