ArticleQuantitative imaging in medicine and surgery2026
Activation likelihood estimation of convergent resting-state brain alterations in diarrhea-predominant IBS: a systematic review and meta-analysis.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disorder. Resting-state functional magnetic resonance imaging (rs-fMRI) has provided valuable insights into brain activity alterations; however, despite the increasing number of neuroimaging studies, the results remain inconsistent. This study aimed to perform a coordinate-based activation likelihood estimation (ALE) meta-analysis to identify functionally impaired brain regions showing convergent alterations in IBS-D. Methods: Coordinate-based ALE was applied to rs-fMRI studies of IBS-D that were systematically retrieved from multiple databases. Statistical significance was determined using cluster-level family-wise error correction, and the robustness of the results was further evaluated through a jackknife sensitivity analysis. Results: The ALE meta-analysis revealed two clusters of hyperactivity in IBS-D patients compared to healthy controls (HCs). The first cluster was located in the right cerebellar culmen (69.4%), extending to the right cerebellar lingula (7.7%) and left fastigial nucleus (22.9%). The second cluster was located in the right parahippocampal gyrus [78.6%, Brodmann area (BA) 36], extending to the right fusiform gyrus (18.6%) and right sub-gyral area of the parahippocampal gyrus (2.8%). In contrast, one cluster of hypoactivity was observed in the right superior frontal gyrus (67.6%, BA 10) and right middle frontal gyrus (32.4%, BAs 9 and 10). The jackknife sensitivity analysis confirmed the robustness of these clusters across all iterations. Conclusions: This ALE meta-analysis identified functionally impaired brain regions consistently altered in IBS-D, providing novel insights into its central mechanisms and potential targets for future research and therapeutic interventions.
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