ArticleQuantitative imaging in medicine and surgery2026
Correlation of pretreatment imaging features with lung shunt fraction in patients with large hepatocellular carcinoma (maximum diameter >8 cm) planned for
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Yttrium-90 selective internal radiation therapy ( Methods: A retrospective analysis was conducted on 218 patients with HCC in whom LSF was measured via hepatic arteriography with Results: The median LSF was 10.1% (range, 1.5-64.8%), and 108, 57, and 53 patients had LSF <10%, 10-20%, and >20%, respectively. Univariate analysis indicated that maximum tumor diameter, tumor burden, portal vein tumor thrombus, hepatic vein invasion/occlusion, and abnormal intratumoral vessels were correlated with LSF (all P values <0.05). Overall ordered logistic regression identified the independent risk factors for elevated LSF to be hepatic vein invasion or occlusion [odds ratio (OR) =5.564, 95% confidence interval (CI): 2.859-11.182, P<0.001; area under the curve (AUC) =0.701, 95% CI: 0.620-0.782] and maximum tumor diameter (OR =2.340, 95% CI: 1.240-4.416, P=0.009; AUC =0.653, 95% CI: 0.575-0.732), with an overall prediction accuracy of 57.34%. Combining the two factors improved the AUC for predicting LSF >20% to 0.736 (95% CI: 0.663-0.808), with a 71.7% sensitivity and a 68.5% specificity. In large tumors (>8 cm), the binary logistic regression confirmed the independent risk factors of increased LSF to be hepatic vein invasion or occlusion (OR =6.452; 95% CI: 2.413-17.253; P<0.001), with a prediction accuracy of 74.24%. Conclusions: Hepatic vein invasion and maximum tumor diameter are independent risk factors for elevated LSF in patients with HCC scheduled to undergo
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