ArticleQuantitative imaging in medicine and surgery2026
Elevated echocardiographic pulmonary to left atrial ratio (ePLAR) in high-altitude residents.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Population-specific reference values for the echocardiographic pulmonary to left atrial ratio (ePLAR) are lacking for high-altitude residents. This study aimed to establish ePLAR reference values for healthy individuals at extreme high altitude and identify its key determinants. Methods: In this cross-sectional study, we enrolled 120 healthy adults (aged 18-75 years) permanently residing at an altitude of ≥4,000 meters and 120 age- and sex-matched lowland controls (≤5 meters). All participants underwent comprehensive echocardiography. The ePLAR (m/s) was calculated as the ratio of peak tricuspid regurgitation velocity (TRV Results: High-altitude residents demonstrated significantly higher ePLAR values compared to lowlanders [0.31 (0.23-0.39) Conclusions: This study establishes the first ePLAR ranges for extreme high-altitude populations, which are substantially elevated compared to lowland values. The ePLAR is independently determined by cardiopulmonary (TAPSE), hematological (hemoglobin), and demographic factors (age, sex, BMI, SBP). These altitude-specific benchmarks are essential for cardiovascular risk assessment and pulmonary hypertension screening in high-altitude populations.
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