ArticleQuantitative imaging in medicine and surgery2026
Paraspinal muscle degeneration patterns in degenerative spinal deformity: a histological, morphological, and muscle functional comparison.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Degenerative spinal deformity (DSD) is an umbrella term for three-dimensional (3D) spine malalignment. Paraspinal muscle (PSM) degeneration has been widely implicated in the pathology and progression of DSD. However, little is known about the differences in the degeneration patterns of PSM in deformity subtypes. This study aimed to explore the degeneration patterns of PSM in DSD subtypes. Methods: A total of 65 patients with degenerative lumbar scoliosis (DLS), 57 with degenerative lumbar kyphosis (DLK), and 62 patients with lumbar spinal stenosis (LSS) were included. Hematoxylin and eosin (H&E) staining, Sirius Red staining, and Oil Red O staining was performed to assess histological change in multifidus muscle (MF). The relative cross-sectional area (rCSA) and percentage of fat infiltration area (%FIA) of MF and erector spinae (ES) were measured at the L2/3 level. Maximal voluntary exertion (MVE) and endurance time (ET) were examined. Results: Histologically, significant adipocytes deposition was observed in the concave side of DLS, whereas predominant muscle fibrosis was found in the convex side of DLS and in DLK. Patients with DLK exhibited a smaller functional cross-sectional area (fCSA) of the ES compared with patients with DLS (56.7±9.4 Conclusions: PSM degeneration patterns vary among the subtypes of DSD. These findings may provide new insights for clinical diagnosis and treatment.
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