ArticleFrontiers in neurology
Acute-phase clinical phenotyping stratifies long-term cognitive and functional outcomes in cerebral venous sinus thrombosis.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Current prognostic models for cerebral venous sinus thrombosis (CVST) inadequately predict long-term cognitive and functional outcomes, focusing primarily on survival. We aimed to develop and validate a simple, acute-phase clinical phenotyping system to stratify the risk of these disabling sequelae. Methods: In this retrospective cohort study, consecutive adult CVST patients between 2014 and 2024 were included. Patients were classified into three acute-phase phenotypes: Benign Intracranial Hypertension, Focal Brain Injury, and Diffuse Brain Injury. Long-term outcomes (cognitive impairment, depressive symptoms, return to work) were assessed at a median of 1 year post-onset via telephone interview. Multivariable logistic regression analyses adjusted for key confounders were used to determine independent associations. Results: Among 110 patients, the prevalence of the Benign, Focal, and Diffuse Brain Injury phenotypes was 33.6% ( Conclusion: A simple, bedside-accessible clinical phenotyping system effectively stratifies long-term risk in CVST patients. The Diffuse Brain Injury phenotype warrants early, multidisciplinary intervention to mitigate its multifaceted poor prognosis.
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