ArticleFrontiers in neurology
Local delivery of nerve growth factor in traumatic optic neuropathy: neuroprotective effects in a rat model.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: In the present study, we established a rat model of optic nerve injury to evaluate whether direct local delivery of neurotrophic agents following traumatic optic neuropathy (TON) enhances retinal ganglion cells (RGCs) survival and its potential effects on axonal regeneration. Methods: Forty-eight rats were randomly assigned to treatment ( Results: Compared with the control group, H&E staining showed better preservation of retinal morphology in the mNGF-treated group. CTB-488 anterograde tracing showed no significant differences between groups in mean axonal fluorescence intensity at the injury site. Immunofluorescence analysis revealed significantly higher RGC survival in the treatment group at days 1 (1/2 retinal eccentricity), 8 (1/6 and 1/2 eccentricities), and 14 (1/6 eccentricity). Conclusion: In this Sprague-Dawley rat model of optic nerve injury, direct local delivery of mNGF may enhance RGC survival with effects showing time-dependent and spatially heterogeneous patterns. However, this intervention does not significantly promote the survival or regeneration of optic nerve axons.
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