Evidence map›Paper›PMID 42147816›Full record

ArticleHuman mutation2026

Cédric Facon, Catherine Vermaut, Lucie Delattre, Cathy Flament, Antoine Dardenne, Afane Brahimi, Sophie Lejeune, Stéphane Cattan, Francoise Bonnet, Noémie Basset and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Human mutation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Cédric FaconEpiCARe,Team Univ. Lille, Inserm, CHU Lille, CNRS, Centre Oscar Lambret, U1366-UMR9020, CRCLille (Cancer Research Center of Lille), Lille, France, chru-lille.fr.ORCID https://orcid.org/0009-0006-3499-1334
Catherine VermautMolecular Oncogenetics Unit, Department of Biochemistry and Molecular Biology, Lille University Hospital, Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0002-3956-5864
Lucie DelattreMolecular Oncogenetics Unit, Department of Biochemistry and Molecular Biology, Lille University Hospital, Lille, France, chru-lille.fr.
Cathy FlamentMolecular Oncogenetics Unit, Department of Biochemistry and Molecular Biology, Lille University Hospital, Lille, France, chru-lille.fr.
Antoine DardenneGeneral and Digestive Surgery, Saint-Antoine Hospital, APHP, Sorbonne University, Paris, France, sorbonne-universites.fr.ORCID https://orcid.org/0009-0005-9059-7975
Afane BrahimiClinical Genetics Department, Lille University Hospital, Lille, France, chru-lille.fr.ORCID https://orcid.org/0009-0004-3657-4724
Sophie LejeuneClinical Genetics Department, Lille University Hospital, Lille, France, chru-lille.fr.
Stéphane CattanDigestive Oncology Unit, Lille University Hospital, Lille, France, chru-lille.fr.ORCID https://orcid.org/0009-0002-0437-1063
Francoise BonnetCancer Genetics Department, Institut Bergonié, Bordeaux, France.
Noémie BassetDepartment of Medical Genetics, Pitié-Salpêtrière Hospital, APHP, Sorbonne University, Paris, France, sorbonne-universites.fr.
Anika BensenCancer Genetics Department, Institut Bergonié, Bordeaux, France.
Anais DupréCancer Genetics Department, Institut Bergonié, Bordeaux, France.
Pascaline BerthetOncogenetics Department, Centre François Baclesse, Caen, France.
Marion DhoogeGastroenterology Unit, Cochin Teaching Hospital, APHP Centre Université de Paris, Paris, France.
Chrystelle ColasGenetics Department, Institut Curie, PSL Research University, Paris, France, univ-psl.fr.ORCID https://orcid.org/0000-0001-9146-9346
Emmanuelle Mouret-FourmeGenetics Department, Institut Curie, PSL Research University, Paris, France, univ-psl.fr.
Hélène DelhomelleGenetics Department, Institut Curie, PSL Research University, Paris, France, univ-psl.fr.
Sophie NambotOncogenetics Unit, Centre de Lutte Contre le Cancer Georges François Leclerc-UNICANCER, Dijon, France.ORCID https://orcid.org/0000-0002-9630-5049
Amandine BaurandOncogenetics Unit, Centre de Lutte Contre le Cancer Georges François Leclerc-UNICANCER, Dijon, France.
Marc PlanesGenetics Department, Brest University Hospital, Morvan Hospital, Brest, France.
Julie MenjardGenetics Department, Brest University Hospital, Morvan Hospital, Brest, France.
Patrick R BenusiglioGeneral and Digestive Surgery, Saint-Antoine Hospital, APHP, Sorbonne University, Paris, France, sorbonne-universites.fr.ORCID https://orcid.org/0000-0003-1003-1997
Pascal PignyEpiCARe,Team Univ. Lille, Inserm, CHU Lille, CNRS, Centre Oscar Lambret, U1366-UMR9020, CRCLille (Cancer Research Center of Lille), Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0003-3926-4487
Marie-Pierre BuisineEpiCARe,Team Univ. Lille, Inserm, CHU Lille, CNRS, Centre Oscar Lambret, U1366-UMR9020, CRCLille (Cancer Research Center of Lille), Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0002-3255-5380
Julie LeclercEpiCARe,Team Univ. Lille, Inserm, CHU Lille, CNRS, Centre Oscar Lambret, U1366-UMR9020, CRCLille (Cancer Research Center of Lille), Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0003-1130-7211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constitutional epimutations of the

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisDNA MethylationMosaicismMutL Protein Homolog 1AdultEpigenesis, GeneticFemaleGenetic TestingHumansMaleMiddle AgedMutationPromoter Regions, GeneticMLH1 protein, humanMutL Protein Homolog 1Lynch syndromeMLH1 constitutional epimutationMLH1-methylated tumorsmosaic promoter methylationoncogenetics

Identifiers

PMID42147816
PMCPMC13173757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.