Evidence map›Paper›PMID 42147801›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2026

Evaluation of a PET Insert for Trimodal Imaging: A Step Toward PET/MRI-Guided Focused Ultrasound.

F Lopez-Berenguer, A Gonzalez-Montoro, M Freire, A González-Tamarit, S Jiménez-Serrano, L F Vidal, M Gil, F Loignon-Houle, I Torres, J L Sachs and 25 more

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

F Lopez-BerenguerDetectors for Molecular Imaging Laboratory, Institute of Instruments for Molecular Imaging, 46022 Valencia, Spain.ORCID 0009-0004-6381-6442
A Gonzalez-MontoroDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-7319-4278
M FreireDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-1150-383X
A González-TamaritDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.
S Jiménez-SerranoDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0003-2917-6053
L F VidalDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.
M GilDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.
F Loignon-HouleDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-8931-2016
I TorresDepartment of Nuclear Medicine, Hospital La Fe, 46026 Valencia, Spain.
J L SachsDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22904 USA.
J V RispoliDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0000-0003-4514-3390
N TustisonDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0000-0001-9418-5103
S S BerrDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22904 USA.
M B WilliamsDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0000-0002-3549-9097
D AndrésCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-7588-6155
J J Rodríguez-GarcíaCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.
J L Alonso-RamosCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-4172-5492
N JiménezCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-6539-670X
A CarriónCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.
F CamarenaCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.
T Guallart-NavalCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.
J M AlgarínCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0003-2644-7225
R BoschCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.
E PallásCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-7791-6592
J AlonsoCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0002-2721-1380
N D SheybaniBiomedical Engineering Society, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0000-0002-1137-058X
S MaslovaBiomedical Engineering Society, University of Virginia, Charlottesville, VA 22904 USA.
T SherlockBiomedical Engineering Society, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0000-0001-6407-7013
A ThedeBiomedical Engineering Society, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0009-0009-1707-3306
Z E F DemirBiomedical Engineering Society, University of Virginia, Charlottesville, VA 22904 USA.ORCID 0000-0002-8289-3118
M HochBiomedical Engineering Society, University of Virginia, Charlottesville, VA 22904 USA.
J HeDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22904 USA.
J M BenllochCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-6073-1436
M J Rodríguez-ÁlvarezCentro Mixto CSIC and the Instituto de Instrumentación para Imagen Molecular, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-8333-8792
A J GonzálezDetectors for Molecular Imaging Laboratory, the Instituto de Instrumentación para Imagen Molecular, and the Centro Mixto CSIC, Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-6742-5626

Funding

Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
Fabrication and Testing of a Novel PET insert for Simultaneous PET/MRIR01EB029450 · NIBIB · UNIVERSITY OF VIRGINIA · PI BERR, STUART S., GONZALEZ MARTINEZ, ANTONIO · 2020 to 2024
$2.7M
Immunoengineering Next-Generation Cancer Therapies with Focused UltrasoundDP5OD031846 · OD · UNIVERSITY OF VIRGINIA · PI SHEYBANI, NATASHA DIBA · 2021 to 2025
$2.0M
NCI NIH HHS T32 CA009109NIBIB NIH HHS R01 EB029450NIH HHS DP5 OD031846
6 · The paper itself

Abstract

Combining positron emission tomography (PET) with magnetic resonance imaging (MRI) and focused ultrasound (FUS) has emerged as a promising hybrid technique in the medical imaging field. Despite the potential benefits of using simultaneous PET and MRI acquisitions to monitor therapeutic effects and ensure precision and safety during FUS applications, no commercial or academic PET/MRI-guided FUS system (referred in the following as trimodal PET-MRI-FUS) exists. This work presents the design and evaluation of a preclinical PET insert for simultaneous operation with MRI and FUS systems. The proposed PET insert is based on monolithic LYSO crystals arranged in two octagonal rings that define inner and outer diameters of 72 and 114 mm, respectively, with an axial length of 67 mm. The system performance was evaluated according to the NEMA NU 4 2008 protocol. It achieves a uniform spatial resolution of ~0.9 mm along the whole PET Field of View (FOV) when enabling Depth of Interaction (DOI) capabilities. Moreover, we found a sensitivity peak of 3.8% for an energy window of 255-766 keV and a peak noise equivalent count rate peak of 80 kcps at an activity of 19 MBq. The compatibility of the PET insert with both low- and high-field MRI systems, as well as with custom and commercially available FUS devices, was studied using phantoms and in vivo experiments, respectively. The results of the trimodal tests have proven that the PET insert works simultaneously with both MRI and FUS systems.

Indexed as

Focused ultrasound (FUS)magnetic resonance imaging (MRI)positron emission tomography (PET)trimodal imaging

Identifiers

PMID42147801
PMCPMC13175119

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.