ArticleCureus2026
Clinical Outcomes Associated With In-Hospital Versus Delayed Outpatient Initiation of Sacubitril/Valsartan in Patients With Heart Failure With Reduced Ejection Fraction.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart failure with reduced ejection fraction (HFrEF) remains associated with high rates of hospitalization and early readmission, with approximately 20-25% of patients readmitted within 30 days. Sacubitril/valsartan is a key component of guideline-directed medical therapy, but the optimal timing of initiation during hospitalization versus after discharge remains uncertain.
objectiveThis study aimed to evaluate whether initiation of sacubitril/valsartan during hospitalization is associated with improved short-term outcomes compared with delayed outpatient initiation.
methodsThis retrospective cohort study used the MIMIC-IV database. Adult patients hospitalized with HFrEF who received sacubitril/valsartan were included. Patients were classified into in-hospital initiation and delayed outpatient initiation groups based on medication timing. The primary outcome was 30-day hospital readmission, and the secondary outcome was in-hospital mortality. Multivariable logistic regression was used to assess associations after adjustment for age, sex, race, and the Charlson Comorbidity Index.
resultsA total of 4,156 hospitalizations were included. There was no significant association between timing of sacubitril/valsartan initiation and 30-day readmission (aOR=0.91; 95% CI: 0.50-1.67; p=0.764). Higher comorbidity burden was associated with increased readmission risk (aOR=1.04; 95% CI: 1.00-1.07; p=0.035). No significant difference in in-hospital mortality was observed between groups.
conclusionTiming of sacubitril/valsartan initiation was not associated with short-term outcomes. Comprehensive management strategies beyond the timing of therapy may be important for improving outcomes in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.