ArticleCureus2026
The Paradox of Prevention: How Prophylactic Surgery Accelerated Decline in Metastatic Cancer.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic castration-resistant prostate cancer (mCRPC) commonly involves bone metastases, with a high risk of pathological fractures that can lead to significant morbidity. Prophylactic fixation is often recommended based on scoring systems like Mirels. However, the decision to proceed with major surgery in elderly, frail patients with advanced disease poses complex challenges, as the physiological stress of surgery may outweigh its potential benefits. We present the case of an 86-year-old man with end-stage mCRPC and high-risk bilateral proximal femoral lesions who underwent guideline-concordant prophylactic bilateral cephalomedullary nailing. Prior to surgery, a goals-of-care discussion was conducted in which the risks of postoperative complications and potential functional decline were reviewed; the patient demonstrated understanding and expressed a preference to proceed with surgery to reduce his pain and the risk of catastrophic fracture and preserve mobility. While the surgery successfully prevented fractures, his postoperative course was marked by severe anemia, transfusion reactions, hematuria, and a rapid functional decline. Within weeks, he became non-ambulatory and dependent on activities of daily living. Despite multidisciplinary management, he transitioned to home hospice within six weeks of surgery to prioritize comfort and quality of life. This case underscores the critical disconnect that can occur between technical surgical success and patient-centered outcomes in advanced cancer. While clinical guidelines and scoring tools like Mirels provide valuable direction, they do not account for patient frailty, life expectancy, or functional reserve. In this instance, the intervention may have inadvertently hastened the patient's decline, emphasizing the importance of early palliative care involvement and shared decision-making that incorporates discussions around prognosis, functional outcomes, and individual goals of care. In patients with advanced malignancy and limited reserve, the physiological burden of prophylactic surgery may undermine their remaining quality of life. A nuanced, multidisciplinary approach is essential to align treatment plans with patient values and priorities.
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Registered trials
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