ArticleCureus2026
Nodulo-Infiltrative Subtype of Basal Cell Carcinoma With Follicular and Sebaceous Differentiation.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basal cell carcinoma (BCC) is the most common cancer and typically presents as a slow-growing pearly papule with telangiectasias on sun-damaged skin, particularly the head and neck.Although BCC metastasizes rarely, delayed treatment can lead to significant local tissue destruction. Common subtypes of BCC include nodular, micronodular, superficial, and infiltrative. Rarer variants with sebaceous or follicular differentiation have also been reported. We describe a case of a 69-year-old woman with a 7 mm red papulonodule on the upper back. Shave biopsy revealed nodulo-infiltrative BCC with sebaceous and follicular differentiation. Histopathology showed sebaceous cells with vacuolated, foamy cytoplasm expressing epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA). Follicular differentiation was characterized by infundibular cyst-like formations and cellular arrangements mimicking telogen follicles. These rare subtypes, particularly in combination, pose diagnostic challenges. Increased awareness of their unique characteristics is essential to avoid misdiagnosis and ensure appropriate management. Further studies are needed to clarify their clinical behavior and outcomes.
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