Evidence map›Paper›PMID 42147495›Full record

ArticleBiomedical signal processing and control2026

Self-supervised Deep Learning for Denoising in Ultrasound Microvascular Imaging.

Lijie Huang, Jingyi Yin, Jingke Zhang, U-Wai Lok, Ryan M DeRuiter, Jieyang Jin, Kate M Knoll, Kendra E Petersen, James D Krier, Xiang-Yang Zhu and 8 more

Abstract read
In one paragraph

Article in Biomedical signal processing and control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lijie HuangDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Jingyi YinDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Jingke ZhangDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
U-Wai LokDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Ryan M DeRuiterDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Jieyang JinDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Kate M KnollDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Kendra E PetersenDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
James D KrierDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Xiang-Yang ZhuDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Gina K HesleyDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Kathryn A RobinsonDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Andrew J BentallDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Thomas D AtwellDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Andrew D RuleDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Shigao ChenDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
Chengwu HuangDepartment of Radiology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.

Funding

Renal Microvessel Imaging for Characterization of Chronic Kidney DiseaseR01DK129205 · NIDDK · MAYO CLINIC ROCHESTER · PI Shigao Chen · 2023 to 2026
$2.0M
NIDDK NIH HHS R01 DK129205
6 · The paper itself

Abstract

Ultrasound microvascular imaging (UMI) has emerged as a powerful, noninvasive modality for visualizing the microvasculature, offering valuable insights into underlying pathological and physiological processes. However, it is often hindered by low signal-to-noise ratio (SNR) of unfocused plane wave imaging, especially in contrast-free or deep tissue scenarios, which may impair subsequent vascular quantification and reliable disease diagnosis. To address this challenge, we propose Half-Angle-to-Half-Angle (HA2HA), a self-supervised denoising framework specifically designed for UMI. HA2HA constructs training pairs from complementary angular subsets of beamformed radio-frequency (RF) blood flow data, across which vascular signals remain consistent while noise varies. HA2HA was trained using

Indexed as

denoisingDopplerNoise2Noiseradio-frequencySelf-supervised deep learningultrasound microvascular imaging

Identifiers

PMID42147495
PMCPMC13178498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.