ArticleMolecular therapy. Advances2026
Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and immune regulation.
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Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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Who cites it
2 citing papers in PubMed.
- Tacrolimus-resistant regulatory T cells: Combining the best of both worlds?Molecular therapy. Advances · 2026Article
- Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance.Frontiers in immunology · 2026Review
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Authors and funding
53 authors.
Ghazaleh ZarrinradCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Lisa-Marie BurkhardtCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Claudia Beltran-MestresCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Silvina Romero-SuárezCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Dimitrios Laurin WagnerBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Stephan SchlickeiserBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Maik SteinBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Désirée Jacqueline WenderingBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Iván Juky Carrera Diaz de la CebosaCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Lukas EhlenBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Frederik HammBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Gavin L KurganIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Pawel DurekGerman Rheumatism Research Center, Institute of Leibniz-Gemeinschaft, Charitéplatz 1, 10117 Berlin, Germany.
Frederik HeinrichGerman Rheumatism Research Center, Institute of Leibniz-Gemeinschaft, Charitéplatz 1, 10117 Berlin, Germany.
Anamika GiriBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Yaolin PuCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Kristy OuBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Henrike HoffmannCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Sandra MuenchCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Insa StueweCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Sven DollingCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Oliver McCallionTransplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Jaspal KaedaCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Jonas KathBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Sarah SchulenbergCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin School for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Niklas WieseCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin School for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Abdolreza NazariCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Lena PeterBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Samira PichtCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin School for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Andrea Sánchez-PeñaIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Olalekan UsmanIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Christian BrommelIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Rolf TurkIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Garrett RettigIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Morgan SturgeonIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Thomas L OsborneIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Ashley JacobiIntegrated DNA Technologies (IDT) Inc, Coralville, IA 52241, USA.
Rebecca FriedrichBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Masako Monika KaufmannInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, 79106 Freiburg, Germany.
Julia KlermundInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, 79106 Freiburg, Germany.
Simon FinkNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Markus F TemplinNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Andy RoemhildCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Daniel KaiserCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Berlin Center for Advanced Therapies, Augustenburger Platz 1, 13353 Berlin, Germany.
Oliver KleinBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, 13353 Berlin, Germany.
Toni CathomenInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, 79106 Freiburg, Germany.
Mir-Farzin MashreghiGerman Rheumatism Research Center, Institute of Leibniz-Gemeinschaft, Charitéplatz 1, 10117 Berlin, Germany.
Fadi IssaTransplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Julia K PolánskyBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Hans-Dieter VolkCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Michael Schmueck-HenneresseBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Petra ReinkeCharité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, 13353 Berlin, Germany.
Leila AminiBerlin Institute of Health (BIH) at Charité - Universitaetsmedizin Berlin, BIH-Center for Regenerative Therapies (BCRT), Charitéplatz 1, 13353 Berlin, Germany.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unwanted alloimmune responses are a central driver of solid organ transplant rejection and currently managed with life-long immunosuppression, which imposes substantial risks and burdens on patients. Adoptive transfer of regulatory T cells (Tregs) offers a strategy to restore immunological balance and reduce long-term adverse effects of generalized immunosuppression. However, although Tregs can potently inhibit incipient immune activation, they struggle to suppress established memory effector T cells, necessitating the continued use of immunosuppression. Calcineurin inhibitors such as Tacrolimus effectively control both, newly activated and pre-existing effector T cells, but unfortunately, they also impair Treg function. Therefore, we hypothesized that gene-editing of Tregs inducing tacrolimus resistance (FKBP12
Indexed as
adoptive T cell therapyimmune regulationimmunosuppressionorgan transplantationsolid organ transplantationTreg
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