Evidence map›Paper›PMID 42147414›Full record

ArticleMacromolecules2026

Programmable Electrostatics in Charge-Patterned Polypeptoid Micelles Probed by Small-Angle Neutron Scattering.

Erin Tsai, Chi-Huan Tung, Bailee N Barrett, Guan-Rong Huang, Changwoo Do, Wei-Ren Chen, Donghui Zhang

Abstract read
In one paragraph

Article in Macromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erin TsaiDepartment of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Chi-Huan TungNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Bailee N BarrettDepartment of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Guan-Rong HuangDepartment of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan.ORCID https://orcid.org/0000-0001-6393-9574
Changwoo DoNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID https://orcid.org/0000-0001-8358-8417
Wei-Ren ChenNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.ORCID https://orcid.org/0000-0002-5192-0777
Donghui ZhangDepartment of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, Louisiana 70803, United States.ORCID https://orcid.org/0000-0003-0779-6438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrostatic interactions are key determinants in the assembly and organization of ionic micelles. Here, we synthesized sequence-defined polypeptoid block copolymers with discrete chain lengths and single or triple charged residues arranged in distinct patterns. Model-free small-angle neutron scattering analysis of semidilute polymer solutions at pH 9.0 revealed that intermicellar interactions follow screened Coulomb potentials, with strength and range determined by charge placement. Notably, positioning charged residues near the hydrophobic/hydrophilic block junction enhanced the range of electrostatic repulsion, while split-charge motifs produced stronger, longer-ranged repulsions than block-charge counterparts. Scattering length density profiles provide direct real-space insight into micellar dimension, core density, corona conformation, and solvent penetration. Micellar charge-to-aggregation number analysis further reveals the impact of invasive water and counterion association. This study demonstrates that sequence-specific charge patterning serves as a precise molecular tool for tuning micellar architecture and electrostatic interactions, establishing a foundation for programmable control of self-assembly in crowded environments.

Identifiers

PMID42147414
PMCPMC13173646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.