Evidence map›Paper›PMID 42147273›Full record

ArticleRegenerative biomaterials2026

Regulation of micro-/nanotopography and porosity in biomimetic 3D-printed calcium phosphate ceramic scaffolds for enhanced bone regeneration.

Wenling Dai, Chenxin Liu, Shikui Li, Xingchen Zhao, Yumei Xiao, Changchun Zhou, Kate Jie Zhang Li, Likun Guo, Yujiang Fan, Xingdong Zhang

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In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenling DaiSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Chenxin LiuSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Shikui LiSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Xingchen ZhaoSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Yumei XiaoSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Changchun ZhouSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Kate Jie Zhang LiThe Actions Company, Chengdu, Sichuan 641419, China.
Likun GuoSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Yujiang FanSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
Xingdong ZhangSchool of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610064, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biphasic calcium phosphate (BCP) scaffolds were developed with the pivotal goal to biomimic natural bone tissue and enhance personalized and accurate repair to further fulfill the needs of regenerative medicine. 3D-printed BCP ceramics were extensively utilized in bone repair because of their customizable attributes and excellent biocompatibility. However, 3D printing technology and high-temperature sintering led to the absence of microporous structure and surface nanostructure in the scaffolds, which could hinder protein adsorption, osteogenic differentiation and bone regeneration. In this work, biomimetic BCP scaffolds featuring adjustable porosity and surface micro-/nanotopography were created by integrating 3D printing technology with a hydrothermal process. These BCP scaffolds had abundant micropores, and there were needlelike whiskers and hollow-tube whiskers distributed in them, which demonstrated special physical and biological properties. Compared with scaffolds sintered at high temperature, these BCP scaffolds possessed higher porosity and smaller grain size, thereby enhancing specific surface area (SSA), ions release, adsorption capacity of protein and facilitating osteogenic differentiation

Indexed as

3D printing technologybone regenerationmicro-/nanotopographyporosityporous calcium phosphate ceramics

Identifiers

PMID42147273
PMCPMC13175248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.