Evidence map›Paper›PMID 42147270›Full record

ArticleRegenerative biomaterials2026

Intelligent response hydrogel based on choline phosphorylated chitosan programmed repair of infected wounds.

Min Lu, Tong Sun, Chongxu Tang, Xinmei Zhang, Shuyue Hao, Mei Yang, Qiangwei Xin, Zhongqiang Zhu, Mingming Ding, Jie Weng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Min LuInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Tong SunCollege of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.
Chongxu TangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Xinmei ZhangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Shuyue HaoCollege of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Mei YangDepartment of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Qiangwei XinCollege of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.
Zhongqiang ZhuCollege of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.
Mingming DingCollege of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.
Jie WengInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.ORCID https://orcid.org/0000-0002-7034-3215
Zhiqiang LiInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Xingyu ChenInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Jianshu LiCollege of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The healing of infected wounds is a formidable clinical challenge that demands advanced biomaterials capable of simultaneously eradicating pathogens and orchestrating the complex regenerative process. Herein, we engineered an immunomodulatory and angiogenic multifunctional hydrogel dressing by integrating choline phosphorylated chitosan (CS-MCP) with tetracycline-loaded polydopamine nanoparticles (PDA@TH NPs) for the programmed healing of infected wounds. This composite hydrogel demonstrates on-demand, spatiotemporally controlled therapeutic responses. Under near-infrared (NIR) irradiation, it enables synergistic bactericidal activity through photothermal effects and triggered antibiotic release. Moreover, the system exhibits pH-responsive drug release behavior, specifically targeting the acidic microenvironment of infected tissues. Beyond its potent antibacterial function, the hydrogel actively promotes regenerative processes.

Indexed as

angiogenesisantibacterialhydrogelstimuli-responsivewound healing

Identifiers

PMID42147270
PMCPMC13175249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.