ArticleFrontiers in oncology2026
Comparative molecular analysis of colorectal cancer in Saudi Arabia: distinct genetic alterations and clinical features.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Globally, colorectal cancer (CRC) stands as the third most common type of cancer, a ranking that has remained consistent over recent years. However, the scenario diverges in Saudi Arabia, where CRC ascends to the forefront as the most common cancer among males and the second most prevalent among females. This discrepancy is primarily driven by male demographics, with a staggering 73% of cases diagnosed at a late stage, underscoring a critical public health concern. Delving into the molecular and phenotypic profiles of CRC within the Saudi populace emerges as a crucial stride towards addressing the escalating disease burden afflicting the country. Methods: To unravel the CRC driver molecular landscapes among the Saudi population, we performed Whole Exome Sequencing (WES) of 50 Saudi CRC patients collected by the Colorectal Cancer Research Center at King Saud University Medical Center (KSUMC) with MSS adenocarcinoma tumors. These patients were compared with comparable tumor cohorts from MD Anderson Cancer Center (MDACC) and The Cancer Genome Atlas (TCGA). Results: Tumors from Saudi patients have a significantly lower frequency of Conclusion: The results indicate a distinct mutational landscape of CRC in Saudi Arabia, highlighting the importance of gathering population-specific data in order to inform diagnostic of molecular cancer screening and treatment strategies for patients in Saudi Arabia.
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