ArticleResearch square2026
Protective coinfection: influenza reprograms myeloid cells to limit CD8 T cell-mediated malaria pathology.
Jenna S Reed, Ritika Nayan, Margot Deckers, Douglas H Cornwall, Suzanne Ostrand-Rosenberg, Brian D Evavold, Tracey J Lamb
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Jenna S ReedDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6961-3353 Ritika NayanDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Margot DeckersDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Douglas H CornwallDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Suzanne Ostrand-RosenbergDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Brian D EvavoldDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Tracey J LambDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-0620-3944 Funding
Cross-disciplinary Training in Immunology, Inflammation and Infectious DiseaseT32AI138945 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Tracey Jane Lamb, Matthew A Williams · 2018 to 2026
$1.6MElucidating influenza-induced protection of malaria-associated respiratory distress syndrome in miceR21AI185994 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Tracey Jane Lamb · 2025 to 2026
$417kDefining the role of platelet-mediated glycocalyx breakdown in driving pathogenic CD8 activity during severe malaria.F31HL172638 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jenna Susan Reed · 2024 to 2026
$122kNHLBI NIH HHS F31 HL172638NIAID NIH HHS R21 AI185994NIAID NIH HHS T32 AI138945
6 · The paper itselfAbstract
Malaria-associated acute lung injury (MA-ALI) is a life-threatening complication of malaria driven by pathogenic CD8 T cell responses with no effective pharmaceutical interventions. Here, we show that co-infection with non-lethal influenza/A/HKx31 (X31) protects mice from malarial pulmonary vascular leak and death. X31 co-infection drove the expansion of Ly6C
Indexed as
arginaseCD8 T cellsco-infectionimmune suppressioninfluenzalung injuryMalariamalaria-associated acute lung injurymyeloid cellsPlasmodium
Identifiers
PMID42147182
PMCPMC13174795
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