ArticleResearch square2026
TAR syndrome causal gene RBM8A is critical for embryonic bone development and proper Hedgehog signaling.
Yingwei Mao, Jennifer Mott, Zifei Pei, Jiawan Sun, Choong Lee, Twishi Puri, Zander Sachs, Ana Vargas, Nicholas Blaha, Mabel Tong and 5 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Jennifer MottPennsylvania State University.
Zifei PeiThe Pennsylvania State University.
Choong LeeNew York University Langone Medical Center.
Twishi PuriPennsylvania State University.
Zander SachsPennsylvania State University.
Ana VargasPennsylvania State University.
Nicholas BlahaPennsylvania State University.
Mabel TongPennsylvania State University.
Yong WangThe Pennsylvania State University.
Jiangyang ZhangNew York University Grossman School of Medicine.
Funding
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MCross Scale Interrogation of NPD Genes (SING) in miceRM1MH138309 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VIVEK KUMAR, Yongsoo Kim · 2025 to 2026
$7.3MResearch Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2MTranslational control in neurogenesis by ZNF804AR01MH122556 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAO, YINGWEI, SHI, YONGSHENG · 2020 to 2024
$1.7MDissecting the neuroprotective role of an RNA binding protein in neurodegenerationR21AG094078 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAO, YINGWEI · 2025 to 2025
$429kDelineating molecular mechanism of developmental defects of TAR syndromeR21DE032806 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAO, YINGWEI · 2023 to 2023
$412kDissecting functional roles of schizophrenia risk gene ZNF804a in neural developmentR21MH108983 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAO, YINGWEI · 2016 to 2017
$406kNCATS NIH HHS UL1 TR002014NIA NIH HHS R21 AG094078NIDCR NIH HHS R21 DE032806NIGMS NIH HHS T32 GM108563NIMH NIH HHS R01 MH122556NIMH NIH HHS R21 MH108983NIMH NIH HHS RM1 MH138309
6 · The paper itselfAbstract
RNA-Binding Motif Protein 8A (RBM8A) is a core component of the exon junction complex (EJC), which plays a fundamental role in post-transcriptional RNA regulation. Mutations in the
Indexed as
Hedgehog signalinglimb developmentosteogenesisprimary ciliaRBM8Athrombocytopenia-absent radius (TAR) syndrome
Identifiers
PMID42147171
PMCPMC13174821
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