Evidence map›Paper›PMID 42147138›Full record

ReviewMolecular and clinical oncology2026

Icariin: Multi-target natural products for the multi-stage prevention and treatment of breast cancer (Review).

Yu Wen, Yunyan Chen, Lei Yang, Tingfen Wu, Qinghua Peng, Huiyan Xie, Xuemei Chen

Abstract readReview
In one paragraph

Review in Molecular and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu WenDepartment of Pharmacy, Hospital Traditional Chinese Medicine of Xiamen, Xiamen, Fujian 361009, P.R. China.
Yunyan ChenXiamen Key Laboratory for Research and Transformation of Traditional Chinese Medicine Formulations, Xiamen, Fujian 361009, P.R. China.
Lei YangDepartment of Pharmacy, Hospital Traditional Chinese Medicine of Xiamen, Xiamen, Fujian 361009, P.R. China.
Tingfen WuDepartment of Pharmacy, Hospital Traditional Chinese Medicine of Xiamen, Xiamen, Fujian 361009, P.R. China.
Qinghua PengDepartment of Pharmacy, Hospital Traditional Chinese Medicine of Xiamen, Xiamen, Fujian 361009, P.R. China.
Huiyan XieDepartment of Pharmacy, Hospital Traditional Chinese Medicine of Xiamen, Xiamen, Fujian 361009, P.R. China.
Xuemei ChenDepartment of Pharmacy, Hospital Traditional Chinese Medicine of Xiamen, Xiamen, Fujian 361009, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present review examines the intricate relationship between icariin and breast cancer (BC), encompassing foundational theoretical concepts, epidemiological data, diagnostic methodologies, therapeutic approaches, ongoing debates and prospective future developments. The foundational theoretical concepts address the mechanisms through which icariin influences BC pathogenesis, as well as its pharmacokinetic and pharmacodynamic properties and historical context. The epidemiological section analyzes the global incidence and prevalence of BC, alongside its underlying pathophysiology. Diagnostic methodologies are discussed with a focus on imaging technologies, biomarkers, and the innovative role of icariin in advancing diagnostic techniques. Therapeutic approaches investigate icariin's potential as a chemo-preventive agent, its synergistic interactions with conventional therapies and the outcomes of clinical trials. The section on controversies explores discussions surrounding icariin's efficacy, safety and the associated regulatory and ethical considerations. Future directions emphasize emerging trends, the potential for personalized medicine, and future prospects in BC treatment. The present review aims to offer a comprehensive understanding of icariin's role in BC research and therapeutic applications.

Indexed as

breast cancerchemopreventionicariinmulti-target therapynatural products

Identifiers

PMID42147138
PMCPMC13173617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.