ArticleFrontiers in endocrinology2026
Pre-ablation derived neutrophil-to-lymphocyte ratio is associated with time to complete disappearance after thermal ablation of benign thyroid nodules: a retrospective cohort study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Complete disappearance after thermal ablation for benign thyroid nodules is a time-dependent process with substantial inter-individual variability. Whether baseline systemic inflammatory-immune status contributes to the kinetics of post-ablation absorption remains unclear. Objective: To evaluate the association between pre-ablation derived neutrophil-to-lymphocyte ratio (dNLR) and time to complete disappearance (VRR = 100%) after ultrasound-guided thermal ablation of benign thyroid nodules. Materials and methods: This single-center retrospective cohort analyzed time to ultrasound-defined VRR = 100% as a time-to-event endpoint. Associations were assessed using Cox regression (log2-transformed dNLR per doubling), with stratification by ablation modality when needed. Discrimination was evaluated using Harrell's C-index, and incremental value was assessed by comparing a prespecified clinical-procedural base model with and without dNLR. Results: Over 60 months, 95/187 (50.8%) achieved VRR = 100% (median 37 months). dNLR per doubling was associated with earlier VRR = 100% in univariable analysis (HR 2.44, 95% CI 1.63-3.65; P < 0.001) and remained independently associated in the modality-stratified multivariable model (HR 2.28, 95% CI 1.51-3.43; P < 0.001). The model including dNLR showed moderate discrimination (C-index 0.728, 95% CI 0.675-0.782) and adding dNLR modestly improved discrimination (ΔC-index ≈ 0.02; likelihood ratio test P < 0.001). Conclusions: Higher pre-ablation dNLR was independently associated with earlier complete disappearance after thermal ablation and may provide complementary information for counseling and follow-up planning; however, its incremental discrimination was modest and external validation is needed.
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