ArticleFrontiers in endocrinology2026
Acute administration of Manning compound during the spawning period reduces reproductive success in female zebrafish.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The vertebrate nonapeptide vasotocin (Avp) is evolutionarily conserved and homologous to mammalian vasopressin. Previous work using Methods: Here, we used acute pharmacological manipulation via the Avpr1 receptor antagonist Manning compound alone (dose-response experiment) or in conjunction with PGF Results: In the dose-response experiment, acute female intraperitoneal injection of MC at the lowest dose tested (5 ng/g bodyweight) reduced breeding pair success, quivering behaviour, and the number of released viable eggs compared to saline-injected controls. Whole-body cortisol and reproductive hormone concentrations, clutch size, hatchability and larval survival were unaffected at this concentration. Additional effects on courtship behaviours and increases in estradiol and progesterone concentrations were observed exclusively in females injected with higher doses of MC, suggesting no contribution to the reproductive phenotype observed at the lowest MC dose. The rescue experiment revealed that the phenotype elicited by 5 ng/g bw MC was rescued by co-injection with 5 mg/g bw PGF Discussion: Together, these data suggest that Avp acutely promotes female zebrafish spawning through action on Avpr1 receptors and likely involve downstream activation of PGF
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